Yes, your personal statements are different for every college you apply to. Each college asks you slightly different information. The essay/short answer questions are usually very different since each college and/or major is looking for something different.
In general, applications will ask you about what you have accomplished and how what you have done over your high school years has impacted you. Just be sure to state your positive attributes. For example, state what sports teams you were on, what clubs you were in, if you were on the honor role, leadership positions, or work experience. Colleges love to see that you are independent, involved, and hard-working. Don't be afraid to "brag" a little!
Source(s): current university student
If you are working on your college app essays, you will not believe how helpful this web site (called Essay Hell) is--packed with advice and tips on how to find awesome topics and write "slice-of-life" style essays. It has posts on how to answer all the five Common App prompts, and other popular prompts, including UC, Tufts, Boulders, Transfer students, etc.